In 1218 the Templar fleet traveled from Acre to Egypt. They anchored at the mouth of the Nile River and the crusaders laid siege to Damietta. In the battle Grand Master Guillaume de Chartres was wounded and later died of pestilence which may have been endemic typhus. He was succeeded by Pedro de Montaigu who led the crusaders to victory in Damietta but then failed in an attempt to take Cairo.
Knights Templar page